Luke, Cleo, and Resus battle millions of spiders as they attempt to retrieve the heart of an ancient mummy, which is the third relic Luke needs to escape Scream Street and take his terrified parents home.
Deadstock, the world's greatest zombie rock festival, comes to Scream Street, but when the headlining band is banished, Luke and his friends must restore peace if they plan to continue to search for the relics that will allow Luke to return home.
When Luke Watson turns into a werewolf for the third time, his family is moved to Scream Street, where they and other "unusual lifeforms" are trapped unless Luke and his friends can find six powerful relics.
One week after arriving on Scream Street, Luke Watson is even more determined to find the six relics that will let him return home, but he and his friends must first face problems with the vampires' vital blood supply and with raging sewer rats.